Medetomidine HCl

Description

Medetomidine Hydrochloride exists in the form of white or almost white crystalline powder. It usually appears as a colorless or nearly colorless crystalline solid. Has good solubility in water. At room temperature, approximately 10 grams of water can be dissolved per gram. In addition, it can also be dissolved in organic solvents such as ethanol and methanol. Nuclear magnetic resonance (NMR) spectra, infrared spectroscopy (IR), and ultraviolet visible absorption spectroscopy (UV Vis) can be used for identification and quantitative analysis. Peracid base reaction, Redox and Substitution reaction can participate in a variety of chemical reactions to produce different derivatives or carry out structural modification. Its molecular structure contains benzene ring and imidazole ring, and contains an amino group and a substituted isopropyl group. Relatively stable under dry, dark, and sealed conditions. However, it is sensitive to light and is prone to degradation under sunlight or ultraviolet radiation. Therefore, attention should be paid to avoiding light during the preparation and storage process. It is a commonly used drug in clinical practice, belonging to α Adrenergic receptor agonists. It has the functions of sedation, analgesia and muscle relaxation, and is widely used in Veterinary medicine and human medicine.

We can provide 1- (2,3-dimethylphenyl) ethyl chloride, CAS 60907-88-2, hplc>95% (the analysis result more than 97%) ; (1-bromocyclopentyl)-2-thienyl ketone and n-(trimethyl) imidazole, CAS 18156-74-6 (purity>98%). Medetomidine HCl is a α2-adrenohormone protein kinase inhibitor. Its organic chemical name is (R)-4-(S)-[1-(2,3-dimethylphenyl) ethyl]-1H-imidazolium hydrochloride.

Medetomidine Hydrochloride is a multifunctional drug, which is widely used in Veterinary medicine and human medicine.

1. sedatives:

it is often used as a sedative in veterinary clinical practice. Its sedative effect is very strong and has the characteristics of rapid onset and long duration. By stimulating the central nervous system α 2 Adrenergic receptor, it can inhibit neuronal discharge, thus producing sedative effect. It is usually used for animal surgical procedures, diagnostic tests, and other situations where animals are required to remain stationary.

2. Analgesics:

it has significant analgesic effects and can alleviate pain in animals or humans. It is activated by α Adrenergic receptor inhibits pain conduction in the central nervous system, thereby reducing pain. it is widely used for analgesia management before, during and after surgery, and can also be used to treat acute or Chronic pain caused by trauma, disease or other reasons.

3. Anesthetic aids:

it is often used as an adjuvant of Narcotic, and is used in combination with other anesthetics. It can enhance the effect of Narcotic and reduce the required anesthetic dose, thus reducing the anesthetic risk and adverse reactions. Medetomidine Hydrochloride can be used for the management of anesthesia status during surgical anesthesia, maintenance of anesthesia, and monitoring.

Medetomidine HCl is a selective α2 – adrenoceptor ( α2 – adrenoceptor ) agonist with Ki of 1.08 nM, which is 1620 times higher than that for α1 – adrenoceptor. Medetomidine is a selective α2 – adrenoreceptor agonist with a Ki of 1.08 nM, which is 1620 times higher than that of α1 – adrenoreceptor, and has weak or no binding to other neurotransmitter receptors.

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